Our research group focuses on the fundamental mechanisms of antibiotic resistance and biofilm formation, which represent major global challenges in the treatment of infectious diseases. Our studies particularly investigate antibiotic resistance, biofilm development, and host–pathogen interactions at both molecular and phenotypic levels in clinically important pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus.

Within this scope, the antibacterial and antibiofilm activities of natural and synthetic antimicrobial peptides, as well as natural compounds, are being extensively explored. The effects of these molecules on bacterial membrane integrity, biofilm organization, and the regulation of resistance-associated genes are evaluated not only through in vitro systems but also at the in vivo level using the Caenorhabditis elegans infection model.

In addition, the effects of antimicrobial peptides on cellular responses are comprehensively investigated using proteomic approaches, including alterations in protein expression profiles and the associated signaling pathways. Furthermore, our research group develops next-generation antibiofilm peptide candidates through bioinformatics-based approaches. Through studies conducted on clinical isolates and resistant bacterial strains, we aim to develop alternative and complementary therapeutic strategies against antibiotic resistance.